Benefits
- Offers a full array of protective compounds from cruciferous vegetables, including I3C, DIM, and sulforaphane
- Provides a unique blend of botanicals that improve estrogen metabolism, shifting away from carcinogenic metabolites
- Supports detoxification of a variety of environmental toxins as well as naturally produced hormones by enhancing phase 1 and phase 2 liver enzymes
- Contains botanicals with potent anti-inflammatory activity
- Suitable for vegetarians/vegans
Feature Summary
EstroVantage EM provides a comprehensive formula of plant-based compounds that improve the metabolism of estrogen and its metabolites. Cruciferous vegetables contain a variety of glucosinolates, which some studies have associated with a reduction in cancer incidence when consumed in greater amounts, most likely by causing a shift in metabolism to less carcinogenic estrogen metabolites.1,2 EstroVantage EM contains indole-3-carbinol (I3C) and its metabolite 3,3’-diindolylmethane (DIM), as well as sulforaphane from broccoli powder, all of which have been linked to lower rates of neoplastic changes and a more favourable estrogen profile.3,4,5,6 Not only do these glucosinolates improve estrogen metabolism, they also reduce inflammation by targeting key signalling molecules, such as Nrf2 and NF-?B.7,8
EstroVantage EM also includes other potent plant compounds that reduce inflammation and block carcinogenic pathways. Silymarin, a milk thistle extract, down-regulates gene products involved in the proliferation of tumour cells, along with their invasion, angiogenesis, and metastasis. In addition, it enhances glucuronidation and maintains glutathione levels.9,10,11 This unique combination provides green tea polyphenols, lycopene (tomato extract), turmeric and rosemary extracts, as well as calcium D-glucarate, all of which have been shown to favourably shift estrogen metabolism and reduce carcinogenic risk.12,13,14
Medicinal Ingredients
| Each Vegetarian Capsule Contains: | |
| Calcium D-Glucarate (d-Glucaric Acid Calcium Salt) | 75 mg |
| Indole-3-Carbinol (3-Hydroxymethylindole) | 75 mg |
| Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine) | 50 mg |
| Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene) | 50 mg |
| Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane) | 27.5 mg |
| DIM (3,3’-Diindolylmethane) | 25 mg |
| Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids) | 25 mg |
| Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin) | 25 mg |
| Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf) | 12.5 mg |
| * Epigallocatechin-3-gallate |