5-HTP Supreme is a synergistic formula of 5-hydroxytryptophan (100 mg) and vitamin B6 (20 mg) for supporting overall neurotransmitter metabolism by providing precursors of serotonin. 5-HTP readily enters the blood brain barrier, however conversion into serotonin requires the cofacÌÎ_̴Ìà_tor vitamin B6, which is included in this formula. 5HTP Supreme may be used during the day to support healthy mood or appetite or at bedtime to support sleep.