The 2-hydroxy estrogens, less active than the 16-hydroxy estrogens, generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health. Preliminary studies have examined the efficacy, safety, and optimal supplementation of Indole-3-Carbinol (I3C). A 12-week phase 1 trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.
Recommended Use or Purpose (Adults):Helps support/promote healthy estrogen metabolism and promote/support a healthy estrogen metabolite ratio. Source of antioxidants for the maintenance of good health.
Recommended Dose (Adults):Take 1 capsule one to two times daily, or as recommended by your health professional.
Indole-3-Carbinol (3-Hydroxymethylindole) 200 mg
Non-Medicinal Ingredients:Microcrystalline Cellulose, Leucine, Silicon Dioxide in a Hypromellose (derived from cellulose) capsule.
Risk Information:Consult your health professional if you develop a skin rash. Consult your health professional prior to use if you are taking an antacid, H2 blocker, or proton-pump inhibitor. Consult your health professional if you are taking any medication. Consult your health professional prior to use if you are attempting to conceive. Consult your health professional prior to use if you have a liver disorder or develop liver-related symptoms (e.g., abdominal pain, jaundice), or if you have low estrogen or symptoms of low estrogen. Do not use if you are pregnant or breastfeeding.
Keep out of reach of children. Do not use if security seal inside cap is broken. Store tightly sealed in a cool dry place.