What is PEA?
Palmitoylethanolamide (PEA) is a biologically active, endogenous lipid that is widely distributed throughout the body's tissues and is synthesized on demand. (Gabrielsson 2016) It was first isolated in 1957 as an anti-inflammatory component in egg yolks and is found in many foods. PEA has been studied extensively for its anti-inflammatory, neuroprotective and analgesic properties since the 1970's.* (Hesselink 2013)
PEA plays a key role in maintaining homeostasis by regulating many physiological reactions associated with pain and inflammation. Some chronic conditions can deplete PEA, resulting in a hyper-immune response involving glial, microglial and mast cells. Excessive activation of these satellite, non-neuronal cells has been shown to maintain inflammation and result in neurodegeneration. PEA reduces excessive activation of these cells and decreases neuron loss.* (Raso 2014)
The Research:
In a recent meta-analysis of PEA involving a total of 1484 chronic pain patients, those taking PEA reported pain levels an average of 2.7 points lower than the control groups after 60 days.* (Paladini 2016) 
What is Luteolin?
Luteolin is a potent bioflavonoid with antioxidant and anti-inflammatory properties. Like PEA, luteolin has several mechanisms of action. It inhibits mast cells, as well as mast cell-dependent T cell activation.* (Theoharides 2018) In addition, it modulates microglial activation and inhibits pro-inflammatory cytokine production. (Dirscherl 2010) It also acts on GABA and opioid receptors in the spinal cord.* (Li 2015)
The Synergistic Combination of PEA & Luteolin
When combined, PEA and luteolin show enhanced anti-inflammatory, anti-oxidant and neuroprotective properties. Coadministration of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone. This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.* (Impellizzeri 2018)
Side Effect Free:
PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses. (Gabrielsson 2016)
The recommended daily dose of Mirica is equivalent to the amount of luteolin found in one artichoke. At this dose luteolin is safe and no side effects have been reported.
Miricaå¨ contains OptiPEA, which is produced in the Netherlands under the same standards used in the pharmaceutical industry. At 99.6-100% assay, OptiPEA is unsurpassed in purity and potency.
Mirica is made in a cGMP registered, FDA registered facility in the USA and tested by an independent lab.